• Article  

      Changes in T Cell Receptor Excision DNA Circle (TREC) Levels in HIV Type 1-Infected Subjects Pre- and Post-Highly Active Antiretroviral Therapy 

      Touloumi, G.; Pantazis, N.; Karafoulidou, A.; Mandalaki, T.; Goedert, J. J.; Kostrikis, Leontios G.; Hatzakis, Angelos E. (2004)
      The T cell receptor excision DNA circle (TREC) level is an independent predictor of HIV-1 disease prognosis. We studied the temporal changes in TREC levels prior to and after highly active antiretroviral therapy (HAART) ...
    • Article  

      Development of a capillary electrophoresis-mass spectrometry method for the determination of rivastigmine in human plasma - Optimization of the limits of detection and quantitation 

      Nicolaou, I. N.; Kapnissi‐Christodoulou, Constantina P. (2012)
      A capillary zone electrophoresis-electrospray ionization-mass spectrometry (CZE-ESI-MS) method was developed for the analysis of the acetylcholinesterase inhibitor rivastigmine. Several electrophoretic and ESI-MS parameters ...
    • Article  

      Effect of recent thymic emigrants on progression of HIV-1 disease 

      Hatzakis, Angelos E.; Touloumi, G.; Karanicolas, R.; Karafoulidou, A.; Mandalaki, T.; Anastassopoulou, C. G.; Zhang, L.; Goedert, J. J.; Ho, David D.; Kostrikis, Leontios G. (2000)
      Background. The concentration of T-cell receptor-rearrangement excision DNA circles (TREC) in peripheral-blood T cells is a marker of recent thymic emigrant αβ T cells. We studied the predictive ability of measurements of ...
    • Article  

      Fast Screening of Whole Blood Samples and Pharmaceutical Compounds for Enantiorecognition of Free L-T3, L-T4, and D-T4 

      Mitrofan, Grigorina; Stefan-Van Staden, R. -I; Comnea‐Stancu, Ionela Raluca; Van Staden, J. F.; Bazylak, Grzegorz O.; Kapnissi‐Christodoulou, Constantina P.; Aboul‐Enein, Hassan Y. (2015)
      A fast screening method of whole blood was proposed for enantiorecognition of free L-T3, L-T4, and D-T4. Stochastic microsensors based on four inulins (IN, IQ, TEX, and HD) immobilized on diamond paste (DP) were used for ...
    • Article  

      Hepatitis C infection among intravenous drug users attending therapy programs in Cyprus 

      Demetriou, Victoria L.; Van De Vijver, D. A. M. C.; Hezka, Johana; Kostrikis, Leontios G.; Savvopoulou, Natasa; Georgiades, Neoklis; Charilaou, Charis C.; Argyriou, Argyris; Pavlou, Tina; Platritis, Kyriakos; Veresies, Kyriakos L. (2010)
      The most high-risk population for HCV transmission worldwide today are intravenous drug users. HCV genotypes in the general population in Cyprus demonstrate a polyphyletic infection and include subtypes associated with ...
    • Article  

      MeDIP real-time qPCR of maternal peripheral blood reliably identifies trisomy 21 

      Tsaliki, Evdokia; Papageorgiou, Elisavet A.; Spyrou, Christiana; Koumbaris, George L.; Kypri, Elena; Kyriakou, Skevi; Sotiriou, Chrysovalanto; Touvana, Evi; Keravnou, Anna; Karagrigoriou, Alex; Lamnissou, Klea; Velissariou, Voula; Patsalis, Philippos C. (2012)
      Objective: To reevaluate the efficiency of the 12 differentially methylated regions (DMRs) used in the methylated DNA immunoprecipitation (MeDIP) real-time quantitative polymerase chain reaction (real-time qPCR) based ...
    • Article  

      Medullary cystic kidney disease type 1: Mutational analysis in 37 genes based on haplotype sharing 

      Wolf, M. T. F.; Mucha, B. E.; Hennies, H. C.; Attanasio, M.; Panther, F.; Zalewski, I.; Karle, S. M.; Otto, E. A.; Constantinou-Deltas, Constantinos D.; Fuchshuber, A.; Hildebrandt, F. (2006)
      Medullary cystic kidney disease type 1 (MCKD1) is an autosomal dominant, tubulo-interstitial nephropathy that causes renal salt wasting and end-stage renal failure in the fourth to seventh decade of life. MCKD1 was localized ...
    • Article  

      Molecular epidemiology of hepatitis C infection in cyprus: Evidence of polyphyletic infection 

      Demetriou, Victoria L.; Van De Vijver, D. A. M. C.; Kostrikis, Leontios G.; Chimonides, S.; Evgeniou, N. A.; Hadjigeorgiou-Vounou, E.; Koliou-Mazeri, M.; Papakyriakou, P.; Petsas, L.; Potamitis, G. (2009)
      The genetic diversity of the hepatitis C virus (HCV) in Cyprus is investigated for the first time in this study. Nucleotide sequence analysis of the CORE-E1 and NS5B regions of the HCV genome was performed on blood plasma ...
    • Article  

      Patterns of transmitted HIV drug resistance in Europe vary by risk group 

      Frentz, D.; Van De Vijver, D.; Abecasis, A. B.; Albert, Jan; Hamouda, O.; Jørgensen, L.; Kücherer, C.; Struck, D.; Schmit, J. -C; Vercauteren, J.; Åsjö, Birgitta; Balotta, Claudia; Bergin, C.; Beshkov, Danail; Camacho, Ricardo J.; Clotet, B.; Griskevicius, A.; Grossman, Z.; Horban, A.; Kolupajeva, T.; Korn, K.; Kostrikis, Leontios G.; Linka, K. L. M.; Nielsen, C.; Otelea, D.; Paraskevis, Dimitrios N.; Paredes, R.; Poljak, M.; Puchhammer-Stöckl, E.; Sönnerborg, A.; Stanekova, D.; Stanojevic, M.; Vandamme, A. -M; Boucher, C.; Wensing, A. (2014)
      Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the ...
    • Article  

      Preliminary investigation of using volatile organic compounds from human expired air, blood and urine for locating entrapped people in earthquakes 

      Statheropoulos, Miltiades K.; Sianos, Efstathios; Agapiou, Agapios; Georgiadou, A.; Pappa, Athina A.; Tzamtzis, N.; Giotaki, H.; Papageorgiou, Charalambos Ch; Kolostoumbis, D. (2005)
      A preliminary investigation on the possibility of using volatile organic compounds (VOCs) determination of expired air, blood and urine, for the early location of entrapped people in earthquakes, has been carried out. A ...